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Mt. Kilimounjaro Update

Posted on November 4, 2024 Written by The Nittany Turkey Leave a Comment

I’m back with my oblique title so my Facebook friends can see my posts. I am not certain whether Facebook’s objection is to the word “Mounjaro” or the picture of the Mounjaro injector pen. But I’m tired of messing around trying to outwit their spam algorithm.

This week, before presenting my update, I’ll be looking at the perils of rapid weight loss. This is a topic all of us who take GLP-1 inhibitors must understand. Unfortunately, people who are seeking a miracle cure for obesity, who are sold a bill of goods by profit-oriented weight-loss spas and shady tele-health providers are rarely given the full picture. Also, people who do their research watching GLP-1 proselytizing cheerleaders on YouTube typically find cherry-picked, biased commentary. Those sources emphasize the benefits while either playing down or ignoring adverse effects.

I don’t claim to be a doctor or a medical researcher, and you should not base medical decisions on information or opinions you find here. I merely wish to share some thoughts based on my perusal of the subject. You can investigate further if you wish. Please satisfy yourself that you have examined these potentially harmful effects from all directions. After all, you are (or will be) injecting a foreign substance into your body, so you better know what it will do to you, now and into your future. No drug therapy is completely devoid of side-effects, and Mounjaro and other GLP-1 agonists are no exception. Some of the potential adverse short-term effects are quite serious, while the longer-term, insidious effects are not yet thoroughly studied.

Losing is Winning?

So, you want to lose weight and somehow you got hooked up with a GLP-1 agonist, be it Mounjaro, Zepbound, Ozempic, Wegovy, or generic tirzepatide or semaglutide. Your “medical advisor” told you that you will lose up to 25% of your weight. They started you on a low dose, at which you suffered a few side-effects you felt were tolerable impediments on the way to your goal. A little nausea, some constipation, a feeling of fullness–still worth it. Meanwhile, you are losing weight quickly, which is addictive. If you slow down, they put you on increasingly higher doses, eventually getting you up to the top dose.

All the while, as you fall into the addiction spiral, you acclimate to the side-effects. You compensate by taking fiber supplements for the constipation, and by eating even less. Drunk with the prospect of losing more weight, you starve yourself, lose muscle, and lower your metabolism, while risking some horrible short-term issues like pancreatitis, gall bladder disease, intestinal obstruction, and treatment induced neuropathy of diabetes (TIND). But it is sooooo worth it to shed those unwanted pounds so easily.

Until it isn’t.

I Can Quit!

Like an alcoholic, you indignantly exclaim, “I can quit at any time!” Can you? What happens then? Have you screwed up your metabolism so badly that you’ll gain back 50% of what you lost in a matter of months? Better not quit, then! Can’t risk porking up again! You must do whatever you can do to continue taking your Ozempic. Denmark’s citizens appreciate your support because you and your fat loss colleagues have made Novo Nordisk’s contribution to that small country’s economy greater than the aggregate of all other production of goods and services there. You’re hooked on expensive Ozempic or its GLP-1 cousins for the rest of your life, but you’ll be oh, oh, oh, so healthy!

Well, maybe. Long-term effects of these drugs have not been thoroughly studied. But over the years, certain consequences of rapid weight loss have become known. Some are controversial, and you’ll need to do your own research to decide which ones you need to be concerned about. I will focus on two long-term effects here, namely, muscle loss and decrease in metabolic rate.

Muscle Loss

Losing weight quickly causes muscle loss along with fat loss, at a far greater rate than losing excess weight slowly through controlled diet and exercise. This can be devastating in middle aged and older adults, who are already losing muscle mass due to aging. Poor nutrition can also result in bone loss, which in combination with muscle loss can result in frailty.

In one study, researchers put 25 people on a very low-calorie diet of 500 calories per day for 5 weeks. They also put 22 people on a low-calorie diet of 1,250 calories per day for 12 weeks. After the study, the researchers found that both groups had lost similar amounts of weight. But the people who followed the very low-calorie diet lost over six times as much muscle as those on the low-calorie diet.

Typically, responsible weight-loss clinics counsel their patients to consume enough protein and diligently pursue a resistance exercise program to thwart muscle loss. While these measures slow down muscle loss, the big question is whether they do enough. For older adults, who can not effectively rebuild muscle, the loss can be irreversible. Furthermore, it is difficult to consume enough protein when the appetite suppression effects of GLP-1 drugs kick in. For an obese person who weighs 220 lbs (100 kg), we’re looking at 100-120 grams of protein per day, which is equivalent to a 22-ounce (624 g) ribeye steak. If you’re fatter, you’ll need more.

Rationalization

Some sources rationalize that if you lose a lot of weight, you’ll have lots less to carry, so you’ll need less muscle to support your smaller size. This is equivalent to saying that if your business is losing money, you can fire some employees because you’ll need fewer workers. True, but the bottom line is compromised, and with fewer workers, it will be that much harder to get back to where you were. You’re looking at diminishing returns. Even if you get off the drugs, you’ll need to consume loads of protein for modest gains in muscle mass, and you’ll be looking at gaining lots of weight back in the form of fat.

Metabolic Rate Decreases

The effect of rapid weight loss on metabolic rate has been studied since well before GLP-1 agonist drugs were a gleam in Big Pharma’s eye. Yo-yo dieting has been shown to lower metabolism during each weight-loss cycle. This results in a cumulative effect, making it harder to lose the weight the next time. Your body burns fuel at a lower overall pace, so you must eat less and work harder to lose the same amount of weight.

Recalling the earlier section of this article, rapid weight loss can cause significant muscle loss. Less muscle mass will decrease metabolism. So, it’s a vicious circle.

This brings us to why we have never seen a reunion show of The Biggest Loser contestants, who have been studied by bariatric researchers. You will not see that reunion because most of the contestants have regained much of their former size. Some have even exceeded their starting weight. One study assessed sixteen participants on The Biggest Loser. They lost a mean of 128.5 lbs (58.3 kg) during the competition. But after six years, they regained around 90.4 lbs (41 kg). Additionally, those who maintained a greater weight loss over time also had greater metabolic slowing. So, their metabolism never rebounded after they lost weight.

Slower metabolism leads weight-loss addicts to want to eat even less, thus risking nutritional disorders and more muscle loss. Their aversion to proper nutrition during the down cycle is abetted by the appetite suppression effects of GLP-1 agonists like Mounjaro and Ozempic.

What to Do?

Once again, I’m not here to push advice, just to tell you to keep your mind and your options open. I want to emphasize that there’s no such thing as a free lunch (no pun intended). You might be on Mounjaro for diabetes, and it might be working for you. I do not wish to discourage that therapy, because as the drug insert mantra goes, “your doctor prescribed this drug because its benefits outweigh its side-effects.” Trust your own, local doctor.

But weight-loss drugs have created a cutthroat, competitive, money driven, pay-for-play, highly commercialized healthcare industry segment. I urge caution dealing with tele-health doctors contracted by self-interested compounding pharmacies and med spas to push their drugs. Their impetus is to sell drugs for weight loss, not to look after your overall health. Imagine how they will support you when you develop pancreatitis or cholecystitis, listed adverse effects of Mounjaro. Their lawyers might tell them to refer you to your local face-to-face physician but beyond doing that, keep their mouths shut.

You did consult with your local doctor before you started on your GLP-1 drug, right? At the very least, do you keep your local doctor in the loop while you deal with the tele-health prescriber? Again, you’re injecting a foreign substance into your body that has both positive and negative effects on your overall health. Your doctor needs to be informed and involved.

Be Careful!

In summation, be careful. Resist the temptation to accelerate the process, increasing med doses to sustain a high rate of weight loss. Bigger adverse side-effects kick in at higher doses. Take it slowly. After the initial water weight loss, don’t be disappointed if you lose just a pound or two a week or if you stall for a while on a weight “plateau”. Keep working at it, keep the protein intake up, and be seriously committed to exercise, both resistance and cardio. Make certain that your diet consists of real food, not ultra-processed crap. Eat well and make it count. Do not malnourish yourself in an insane quest to lose weight faster. Nothing good comes easily, and there ain’t no such thing as a free lunch.

My Progress on Mounjaro

With all the caveats I presented above, you would think that I was on the outside looking in, but noooooo, I’ve been taking Mounjaro for twenty-two weeks now for type two diabetes. My doctor prescribed it on June 5. Along with dietary changes and exercise, it has enabled me to achieve decent glucose control. I have also lost about 19% of my body weight.

Average glucose for the week was 99 mg/dL (5.5 mmol/L). This is excellent, and I’m hoping that it stays there or lower. One metabolic keto diet doc whose videos I have been watching likes to use a CGM to measure blood glucose twenty minutes before waking. She categorizes ranges 70-79, 80-89, 90-99 (mg/dL) in descending order of desirabililty. Mind you, she is dealing with non-diabetic or pre-diabetic people. Using the Clarity app, I find that my mean glucose between 6 am and 7 am is 90 mg/dL with a standard deviation of 7. This tells me that if the diet doc–who, by the way, disdains Mounjaro and other GLP-1 drugs–is correct, I still have some work to do.

I lost 1.6 pounds (0.7 kg) this past week, a desirable and sustainable rate. I’m now at 199 lbs (90.5 kg). I am working hard on preserving as much muscle as I can. Right now, physical therapy is helping with that. I’m hoping that the PT torturers will “fix mah back!” so I can resume resistance exercises at home. But I digress. Keeping the muscle mass intact is a priority. Muscle mass weighs more than lard, so if weight loss stalls due to me rocking up, so be it. So, weight loss is relegated to third on the priority list after glucose control and avoiding muscle loss.

Wrapping It Up for Y’all

In the south, the second person singular pronoun is “y’all”, while the second person plural or collective pronoun is “all y’all”. I moved to Florida with my family in 1961, then went away to school, went to work, lived a few places, then moved back to Florida for good in 1976. So, I’m allowed to say y’all.

I hope I have provided some useful information about rapid weight loss, muscle loss, and metabolic slowdown due to losing too much, too fast. I can not hope to even scratch the surface in a weekly blog post, so please do explore these subjects in greater depth. Your curiosity led you here because you care about your health and what a drug like Mounjaro can do. Taking it a step farther to glean more information elsewhere will serve you well.

See you next week!

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Filed Under: Mounjaro

Pwned Again by tOSU

Posted on November 2, 2024 Written by The Nittany Turkey 2 Comments

#4 Ohio State 20, #3 Penn State 13

Despite a valiant effort by Drew Allar, who has not yet completely recovered from the injury he suffered in the Wisconsin game, the Nittany Lions’ offense failed to score a touchdown in their 20-13 loss to the Buckeyes on Saturday. They blew a 10-0 first quarter lead, trailing 14-10 at halftime. Seven of those early points were scored in conjunction with a pick six. The Lions were able to add only a field goal during the remainder of the game.

Red Zone Woes

Each trip to the red zone met with fierce resistance from the tOSU defense, but none of them hurt as much as the fourth quarter drive set up by a 31-yard completion to Tyler Warren. Surely, they would be able to tie the game then, but they screwed it up. With a first-and-ten from the three-yard line, Penn State could not score. After three inside handoffs to Kaytron Allen, they tried a desperate pass play. Tyler Warren was the intended target, but by the time the play developed, the Buckeyes had locked him down with double coverage. Allar took a shot at Khalil Dinkins in the congested end zone and failed, turning the ball over on downs at the one with 4:40 left on the clock.

Against a tired PSU defense, Will Howard ran down the clock, sealing the victory.

Dumbass Penalties

Penn State made some bone-headed errors, including two unsportsmanlike conduct penalties. Jaylen Reed took off his helmet while still on the field, but that penalty came after Penn State’s defensive touchdown, so it did not hurt us badly. On the other hand, Elliot Washington’s shitty on-field behavior converted a defensive stop that gave OSU a fourth-and-four from their own 45 yard-line into a touchdown drive starting with first-and-ten from the Penn State 47. Franklin insinuated that it was a shitty call, but he needs to take responsibility for allowing the young asshole to behave in a juvenile manner in a crucial game. If Washington had acted like a human being instead of a gang-banger, Franklin would have no judgment call to dispute.

Washington’s penalty cost us the game. Not only did it give the ball back to Ohio State after the failed third-down conversion, but also, it handed Big Mo over to the Buckeyes. Franklin did not pull him from the game, either. Intensity in a big game is one thing, like Abdul Carter jumping offside trying to time a snap and giving OSU a first down gift. But stupid-shit celebrations and balls-in-yo-face asshole moves are not what elite teams do. As St. Joe Paterno used to say, “Act like you’ve been there before.”

Yeah, that Washington penalty is one I won’t be forgetting. I’m an old fart who believes in good sportsmanship, which is obviously something that isn’t practiced much anymore. When I see poor sportsmanship exhibited by other teams, it annoys the hell out of me; when I see it exhibited by Penn State, it makes me angry and sick.

Wrapping it Up

All I can say is that I believe Drew Allar gave all he had in a losing effort. The defense, although it gave up 358 yards, kept Penn State in the game, while the offense continually let us all down. Penn State, although possessing less talent, had several chances to win this thing, but squandered all of them. I’ll stop short of blaming Andy Kotelnicki, but there are some issues on his watch in need of correction, including communicating with the quarterback at crucial times, as Allar brought out in his post-game press conference. And Tom Allen needs to impose some discipline on his guys. That bush league shit loses games.

How irate can I be if I counted this one as a loss from before the start of the season straight on through? As late as last Wednesday, I was still predicting the loss. After the opening drive I felt some optimism, which was dampened by their inability to put the ball in the end zone. Then, that pick-six should have been a pivotal play that cemented our dominance, but it was the end. After that, tOSU shut down our offense, and they did what they needed to do to win. And that sucked. The glimmer of hope evaporated and we all went home pissed off.

The silver lining is that Penn State will likely be ranked more realistically than the ridiculous #3 when the first CFP rankings are released.

I’ll be back mid-week for a look at Washington.

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Filed Under: Penn State Football Tagged With: boneheaded penalty

Fleeting Daylight

Posted on November 2, 2024 Written by The Nittany Turkey Leave a Comment

Lazy Time

As the tension builds leading up to the 2024 edition of the Penn State vs. Ohio State rivalry, which we think is a rivalry and they don’t, a little semi-humorous digression is in order.

I published a post titled Time Warp, on March 23, 2007. It remains one of my all-time classics, describing the most traumatic of all my semi-annual daylight savings time clock adjustment fiascoes.

We’ve come a long way since 2007. Computers in all our devices and appliances have a better understanding of what time it is now. Or do they?

So, please tune in to my words of yesteryear as we once again face the pain of the time change.

Time Change Trauma in 2007

Daylight Saving Time Sucks

Let the government handle something and it really gets screwed up! This past weekend, we went on Daylight Savings Time (Summer Time to you English blokes), because Congress, in its infinitely self-perceived wisdom, so decried. It is normally bad enough when the time change occurs on schedule, so it follows that when an act of Congress moves it up by a month, complete chaos will ensue. Accordingly, I spent Sunday completely screwed up.

“Daylight saving just brings a smile to everybody’s faces.”—Rep. Ed Markey, D-Mass., on March 8, 2007.

No Smiles Here

Oh, yeah? Our duly elected representatives just drop bombs like this without considering any impact beyond the end of their noses, or at least past the November ballot box. The last time these dweebs changed the timing, computers did not completely dominate our lives. Superdweeb Jimmy Carter had imposed his “moral equivalent of war” sanctions on energy usage, part of his plan being a temporary measure that gave us Daylight Savings Time for the entire year. As of 1987, the Democrat Congress decided to make a three-week advance in Daylight Savings Time permanent. At least that’s how I remember it. This, of course, put us out of sync with the rest of the civilized world, but what else is new?

Now, via the Energy Policy Act of 2005, Congress is back again dicking with the unknown, but this time computers are a lot smarter and they are not just the tools of dreaded cor-por-a-tions — they pervade just about all aspects of private citizens’ lives. Computerized clocks exist in everything from our cameras to our appliances — and, of course, our indispensable computers, cell phones, and PDAs. And alas, they were all programmed before the enactment and implementation of this latest legislation to screw around with our time!

Out of Sync

So, yesterday, after manually setting about 800 clocks — my wristwatch, my irrigation system, my stove, my microwave, my two cars, my coffee maker (which is not as good as New York City coffee machine), my three programmable thermostats, my two digital cameras, my postage meter, my fax machine, and, of course, my traditional , analog clocks, I next looked at my cell phone. It had the wrong time. Hey, I thought that cell phone networks automatically supplied the time. So, I turned the damn thing off and back on again, and magically, the correct time appeared. Then, I began to tackle the chore of ensuring that my four computers were all in sync.

Without boring you with details of my network — I’m a geek with a couple of back-end servers and some other crap, which I say is necessary for business to rationalize my geekological recreation — I’ll say that the Macintoshes functioned flawlessly, but the Windows systems were so screwed up that by 1 PM I had no idea what the hell time it was. My Windows 2000 Server is the time standard for my network, and it synchronizes with an Internet time standard. It must have waited for a while to change its time. Meanwhile, my XP laptop, which gets its time from the server, was an hour off. So, I changed it.

A Mind of Its Own

At some time later, the server must have changed it back, or forward, or sideways — I don’t know what! While all this was going on, I was applying a Microsoft fix to Outlook, to change all the times for my appointments to conform to the new time scheme. They’re stored internally in Universal Time (the politically correct, sanitized euphemism for what was formerly known as Greenwich Mean Time, lest we give the lily-white Brits too much credit for something used by the Third World, too), to which a bias is applied to the user’s time zone. I viewed the results. Now, people’s birthdays were starting at 11 PM the night before their real birthday and ending at 11 PM on the proper night. So, I changed them back manually. At some later point, presumably when I wasn’t looking, the time on the laptop changed again, which required that I change all those appointments and birthdays manually — again!

At around 1:15 PM, or what I thought was 1:15, I got an e-mail from a friend. The e-mail was time-stamped 12:15. So, I responded, patiently explaining to my friend that the clocks had changed last night and didn’t she get around to changing hers? After all, my computer said it was 1:15, and computers don’t lie — well, mine don’t — even though hers was caught prevaricating in flagrante delicto. Or, so I thought.

The response came back about a half-hour later. “Did you set clocks twice? I have 12:50 pm at my house.”

I looked at the computer. It said 1:51. I looked at my wristwatch. It said 12:51.

So, I changed the computer.

Bad idea.

Completely Out of Control

All the appointment times in Outlook were once again screwed up. So, I ran the Microsoft time zone change utility again and it changed them. Well, yeah — this time it changed all the appointments going forward. I looked at the calendar and decided that I had to change them back.

I came back in a couple of hours. The time on the laptop had changed yet again!

And so it went, for another hour or so until everything was in sync. On my to-do list today is calling the doctor to find out whether my April 16 appointment is at 10 AM, 11 AM, 12 PM, or 1 PM — because it’s been every damn one of those times at one time or another in the past 24 hours according to my Outlook calendar! Perhaps I should cancel the appointment with the internist and make one with a psychiatrist instead. Come take me away to a place where there are no clocks and no computers!

What the hell time is it, anyway???????

Our paternalistic government wants to tell us when to go to sleep and when to wake up. This ongoing battle with our circadian rhythms, under the guise of saving energy, is just another aspect of government intrusion into our private lives. And it does not save any damn energy, according to some studies. From Wikipedia:

Critics argue that the energy savings of DST are overstated, and that DST can sometimes increase energy consumption and peak demand. Also, the rise of air conditioning calls older energy models into question. In 2000 when parts of Australia began DST in late winter, overall electricity consumption did not decrease, but the morning peak load increased.[9] Currently there is no clear evidence that electricity will be saved by the 2007 U.S. rule change.[10].

That same friend who e-mailed me yesterday with the correct time told me today that she has kept a kid home from school today. The kid had stayed up too late last night due to the time change and couldn’t get up this morning.

Master of Our Circadian Rhythms?

Congress cannot legislate our body clocks. I got up at 7:30 this morning. Normally, I get up at 6:30. My ass doesn’t know the difference between standard time and daylight time.

Mark Twain said:

The mania for giving the Government power to meddle with the private affairs of cities or citizens is likely to cause endless trouble, through the rivalry of schools and creeds that are anxious to obtain official recognition, and there is great danger that our people will lose our independence of thought and action which is the cause of much of our greatness, and sink into the helplessness of the Frenchman or German who expects his government to feed him when hungry, clothe him when naked, to prescribe when his child may be born and when he may die, and, in time, to regulate every act of humanity from the cradle to the tomb, including the manner in which he may seek future admission to paradise.

I’ll end this rant with one more tidbit from that Wikipedia article:

Golf courses, convenience stores, and other businesses benefit from extra afternoon sunlight. For example, in the mid-1980s Clorox (parent of Kingsford Charcoal) and 7-Eleven provided the primary funding for the Daylight Saving Time Coalition that successfully lobbied to extend U.S. DST, and both Idaho senators voted to extend DST on the basis of fast-food restaurants selling more French fries made from Idaho potatoes.[11]

DST can adversely affect farmers and others whose hours are set by the sun. For example, grain harvesting is best done after dew evaporates, so when field hands arrive and leave earlier in summer their labor is less valuable.

Clock shifts disrupt sleep patterns, and correlate with decreased economic efficiency. Researchers estimated in 2000 that the daylight-saving effect implies a one-day loss of $31 billion on the NYSE, AMEX, and NASDAQ alone.[12]

Maybe we should send the bill to our congressional geniuses, who continue to find ways to spend our money and invade our lives while achieving no net positive effect upon the general welfare.

What time is it? Time for a change.


That’s the way I felt about it in 2007. The mere memory of that episode makes me want to tear my hair out with each successive instance of the semi-annual time change. Good thing that more things are automated now, and I have fewer manual time adjustments to make. Computers and cell phones now behave around time change time. My thermostats are now synchronized.

Still, the worst are the automatic time setting clocks that pick up their time signals from WWVB — sometimes. The few remaining manual ones, I can handle. But there’s always that nagging doubt in my mind that I’ve forgotten a clock somewhere, and that it will pop up and screw up my day. Time shift paranoia!

And, oh, by the way, that friend who emailed me in 2007 and whose kid stayed home from school due to the time change is now my wife, Jennifer. We were married in 2020.

—TNT 

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